Learning path
In silico funnel

AMP peptide scoring

Didactic ranking based on length, charge, hydrophobicity, and problematic motifs.

Candidate ranking

The goal is to explain filtering criteria, not validate biological activity.

Heuristic mode
Sequence Score Length Charge Hydrophobicity Motifs
GIGKFLHSAKKFGKAFVGEIMNS 85.0 23 +4 0.43 -
KWKLFKKIGAVLKVL 85.0 15 +5 0.60 -
KKLLKLLKKLLKLLK 85.0 15 +7 0.53 -
KLAKLAKKLAKLAK 85.0 14 +6 0.57 -
MKWVTFISLLFLFSSAYSRGVFRR 85.0 24 +4 0.54 -
RRWQWRMKKLG 85.0 11 +5 0.36 -
ACDEFGHIKLMNPQRSTVWY 65.0 20 +1 0.35 -
GGGGGGGGGG -15.0 10 +0 0.00 GGGG

Module README

04 AMP Scoring

Simplified antimicrobial peptide scoring.

The goal is to understand the type of filters that appear in an AMP funnel:

  • Length.
  • Net charge.
  • Approximate hydrophobicity.
  • Potentially problematic motifs.
  • Penalty for non-amino-acid characters.

This scoring is didactic. It does not replace QSAR models, MIC/MBC assays, hemolysis, cytotoxicity, or expert criteria.

Run

From Desarrollo:

python .\04_amp_scoring\scoring_peptidos.py